Baicalein, 12-Lipoxygenase inhibitor (TBI2773)

Description

Product Details

Formal Name: 5,6,7-Trihydroxyflavone

Molecular Formula: C₁₅H₁₀O₅

Formula Weight: 270.24

CAS Number: 491-67-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 20 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

12-Lipoxygenase inhibitor

Functions

Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64 µM for 12-LO and 1.6 µM for 15-LO). Displays anti-inflammatory activity and inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (IC50=36 µM).

Application Procedures

First dissolved in DMSO (up to at least 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 week.