Azoramide, UPR modulator (TBI4629)

Description

Product Details

Formal Name: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide

Molecular Formula: C₁₅H₁₇ClN₂OS

Formula Weight: 308.83

CAS Number: 932986-18-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

UPR modulator

Functions

Azoramide is a modulator of the unfolded protein response (UPR). It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic β cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.