AZD8055, mTOR kinase inhibitor (TBI4816)

Description

Product Details

Formal Name: (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol

Molecular Formula: C₂₅H₃₁N₅O₄

Formula Weight: 465.54

CAS Number: 1009298-09-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

mTOR kinase inhibitor

Functions

AZD8055 is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM). mTOR acts as a nutrient/energy/redox sensor and a controller of protein synthesis – as such it is a very important target for cancer research. It has been investigated as a potential chemotherapeutic for various cancers.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.