AZ3146, Msp1 kinase inhibitor (TBI4778)

Description

Product Details

Formal Name: 9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-one

Molecular Formula: C₂₄H₃₂N₆O₃S₂

Formula Weight: 452.56

CAS Number: 1124329-14-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Msp1 kinase inhibitor

Functions

AZ3146 is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor. Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).

Application Procedures

First dissolved in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.