Autophinib, Autophagy inhibitor (TBI3476)

Description

Product Details

Formal Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine

Molecular Formula: C₁₄H₁₁ClN₆O₃

Formula Weight: 346.70

CAS Number: 1644443-47-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Autophagy inhibitor

Functions

Autophinib inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM). Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells. Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.