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TribioScience  |  SKU: TBI1343-20MG

Aristolochic acid (A&B), PLA2 inhibitor (TBI1343)

$90.00
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TribioScience

Aristolochic acid (A&B), PLA2 inhibitor (TBI1343)

From $90.00

Description

Product Details

Formal Name: 8-Methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (A) and 6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (B)

Alternate Names: Mixture of Aristolochic Acid A and B

Molecular Formula: C17H11NO7 and C16H9NO6

Formula Weight: 341.3 and 311.3

CAS Number: 313-67-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

PLA2 inhibitor

Functions

Phytochemical that acts as an anti-inflammatory and phospholipase A2 (PLA2) inhibitor (IC50 = 40 µM in human neutrophils). Its mutagenic properties cause tumorigenesis and kidney damage in rodent models and in humans. Induces NF-κB, TGF-β, and oxidative stress in mouse kidney, and mitochondrial apoptosis in rat liver.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Option

  • 20 MG
  • 100 MG
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