Argatroban, Thrombin inhibitor (TBI2809)

Description

Product Details

Formal Name: (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid

Alternate Names: Argidipine; MQPA

Molecular Formula: C₂₃H₃₆N₆O₅S

Formula Weight: 508.63

CAS Number: 74863-84.6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Thrombin inhibitor

Functions

Potent and selective thrombin inhibitor (Ki = 19 nM). Prevents platelet-rich arterial thrombosis in a rabbit model. Ameliorates early brain injury and improves neurological outcomes after subarachnoid hemorrhage in a rat model. Reduces breast cancer malignancy and metastasis via osteopontin-dependent and independent mechanisms.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.