AR-A 014418, GSK-3 inhibitor (TBI1195)

Description

Product Details

Formal Name: N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea

Molecular Formula: C₁₂H₁₂N₄O₄S

Formula Weight: 308.32

CAS Number: 487021-52-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

GSK-3 inhibitor

Functions

Selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable. Active in rodent models.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.