AP-18, TRPA1 blocker (TBI1127)

Description

Product Details

Formal Name: 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

Molecular Formula: C₁₁H₁₂ClNO

Formula Weight: 209.67

CAS Number: 55224-94-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

TRPA1 blocker

Functions

TRPA1 channel blocker IC50=3.1-4.5 µM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 µM. Blocks TRPA1 pore dilation (IC50=10.3 µM). An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.