Ansatrienin B, Cytotoxic activity (TBI1576)

Description

Product Details

Formal Name: Fermentation product from Streptomyces sp

Alternate Names: Mycotrienin II; Antibiotic T2311

Molecular Formula: C₃₆H₅₀N₂O₈

Formula Weight: 638.87

CAS Number: 82189-04-6

Purity: >98%

Formulation: Lyophilized

Solubility: Soluble in DMSO, DMF, ethanol and methanol

Storage: -20°C

Stability: ≥ 1 year.

Applications

Cytotoxic activity

Functions

Represents a novel class of ansamycins. Inhibits osteoclastic bone resorption. Potentiates the activity of several clinically useful antitumor agents. Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.

Application Procedures

First dissolved in DMSO, DMF, ethanol and methanol, then diluted to aqueous buffer. Solutions in DMSO, DMF, ethanol and methanol may be stored at -20°C for up to 3 months.