AG-490, JAK2 inhibitor (TBI1091)

Description

Product Details

Formal Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N¬-(phenylmethyl)-2-propenamide

Molecular Formula: C₁₇H₁₄N₂O₃

Formula Weight: 294.31

CAS Number: 133550-30-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml), in DMF (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

JAK2 inhibitor

Functions

A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), in DMF (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.