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TribioScience | SKU: TBI1066-10MG

A-803467, Sodium NaV1.8 channel blocker (TBI1066)

Name: A-803467, Sodium NaV1.8 channel blocker (TBI1066)
Brand: TribioScience
SKU: TBI1066-10MG
Price: 90.0 USD
Availability: InStock

$90.00

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TribioScience

A-803467, Sodium NaV1.8 channel blocker (TBI1066)

From $90.00

Description

Product Details

Formal Name: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide

Molecular Formula: C₁₉H₁₆ClNO₄

Formula Weight: 357.80

CAS Number: 944361-79-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

Sodium NaV1.8 channel blocker

Functions

Potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50’s for rat and human Nav1.8 are 140 nM and 8.0 nM respectively.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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