7,8-Dihydroxyflavone, TrkB agonist/neurotrophic (TBI1174)

Description

Product Details

Formal Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Molecular Formula: C₁₅H₁₀O₄

Formula Weight: 254.25

CAS Number: 38183-03-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

TrkB agonist/neurotrophic

Functions

A selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity. Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the well-characterized N171-82Q Huntington’s disease mouse model. Post-traumatic brain injury-treatment promotes neurogenesis in the hippocampus in a mouse model. Improves motor performance and motor neuronal survival in an ALS mouse model.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.