6-ECDCA (Obeticholic acid), FXR agonist (TBI2838)

Description

Product Details

Formal Name: 3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid

Alternate Names: 6-Ethylchenodeoxycholic acid; 6-ECDCA

Molecular Formula: C₂₆H₄₄O₄

Formula Weight: 420.63

CAS Number: 459789-99-2

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

FXR agonist

Functions

A novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis. Promotes adipocyte differentiation and regulates adipose cell function. Normalizes insulin sensitivity in a rabbit model of metabolic syndrome. A potentially new therapeutic agent for management of non-alcoholic fatty liver disease and NASH. Displays therapeutic benefit in patients with primary biliary cirrhosis. Active in vivo.

Application Procedures

First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.