2′,3′-cGAMP, Endogenous STING agonist (TBI1639)

Description

Product Details

Formal Name: Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt

Alternate Names: 2′,3’cyclic GMP-AMP

Molecular Formula: C₂₀H₂₂N₁₀O₁₃P₂·2Na

Formula Weight: 718.38

CAS Number: 1441190-66-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Endogenous STING agonist

Functions

2′,3′-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist. Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor. Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol. DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.