10074-G5, Myc inhibitor (TBI5627)

Description

Product Details

Formal Name: 7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine

Molecular Formula: C₁₈H₁₂N₄O₃

Formula Weight: 332.30

CAS Number: 413611-93-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Myc inhibitor

Functions

Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity. 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 µM1. It was cytotoxic in c-Myc-overexpressing cell lines (IC50s = 13 to 15 µM) but was not active in vivo due to rapid metabolism. 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes. Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.