1-EBIO, K+ channel activator; Cardiomyocyte differentiation (TBI3204)

Description

Product Details

Formal Name: 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one

Alternate Names: 1-Ethylbenzimidazolinone

Molecular Formula: C₉H₁₀N₂O

Formula Weight: 162.19

CAS Number: 10045-45-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

K+ channel activator; Cardiomyocyte differentiation

Functions

A direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels. Reverses ischemia-induced cognitive impairment and displays neuroprotective effects in ischemia-induced neuronal cell death. Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells. Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.