| Product Name |
Recombinant Human Wingless Type MMTV Integration Site Family, Member 1 (WNT1) Protein |
| Product Overview |
This recombinant human Wingless Type MMTV Integration Site Family, Member 1 (WNT1) protein includes amino acids 28-370aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P04628 |
| Recommended Name |
Proto-oncogene Wnt-1 |
| Gene Name |
WNT1 |
| Synonyms |
INT1; Proto-oncogene Int-1 homolog |
| Species |
Human |
| Predicted Molecular Mass |
66 kDa |
| Expression System |
E.coli |
| Expression Range |
28-370aa |
| Tag |
N-His-GST |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. |
| Subcellular Location |
Secreted, extracellular space, extracellular matrix. Secreted. |
| Protein Family |
Wnt family |
| Associated Diseases |
Osteoporosis (OSTEOP); Osteogenesis imperfecta 15 (OI15); Osteogenesis imperfecta 14 (OI14) |
