LH-846, Casein kinase 1d inhibitor (TBI1465)

Description

Product Details

Formal Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneaceramide

Molecular Formula: C₁₆H₁₃ClN₂OS

Formula Weight: 316.81

CAS Number: 639052-78-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).

Storage: RT

Stability: ≥ 1 year.

Applications

Casein kinase 1d inhibitor

Functions

Potent and selective inhibitor of casein kinase (CK) 1δ., IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.