iJMJD6, Arginine demethylase JMJD6 inhibitor (TBI4039)

Description

Product Details

Formal Name: 3-(3H-Imidazo[4,5-c]pyridine-2-yl)-6-methylchromen-2-one

Alternate Names: WL12

Molecular Formula: C₁₆H₁₁N₃O₂

Formula Weight: 277.30

CAS Number: 899548-78-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 12 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Arginine demethylase JMJD6 inhibitor

Functions

Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins. Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells. Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.

Application Procedures

First dissolved in DMSO (up to 12 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.