| Product Name |
Recombinant Human Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) Protein |
| Product Overview |
This recombinant human Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) protein includes amino acids 114-281aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P50591 |
| Recommended Name |
Tumor necrosis factor ligand superfamily member 10 |
| Gene Name |
TNFSF10 |
| Synonyms |
Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Indu |
| Species |
Human |
| Predicted Molecular Mass |
20.6 kDa |
| Expression System |
E.coli |
| Expression Range |
114-281aa |
| Tag |
C-6His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Apoptosis, Cancer |
| Target Function |
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. Secreted. |
| Protein Family |
Tumor necrosis factor family |
| Tissue Specificity |
Widespread; most predominant in spleen, lung and prostate. |
