| Product Name |
Recombinant Human Antithrombin (AT/SERPINC1) Protein |
| Product Overview |
This recombinant human Antithrombin (AT/SERPINC1) protein includes amino acids 33-464aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P01008 |
| Recommended Name |
Antithrombin-III |
| Gene Name |
SERPINC1 |
| Synonyms |
Antithrombin-III precursor, AT3, AT3D, ATIII, THPH7 |
| Species |
Human |
| Predicted Molecular Mass |
50 kDa |
| Expression System |
E.coli |
| Expression Range |
33-464aa |
| Tag |
N-6His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cardiovascular |
| Target Function |
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. |
| Subcellular Location |
Secreted, extracellular space. |
| Protein Family |
Serpin family |
| Associated Diseases |
Antithrombin III deficiency (AT3D) |
| Tissue Specificity |
Found in plasma. |
