| Product Name |
Recombinant Human Peroxisomal Biogenesis Factor 19 (PEX19) Protein |
| Product Overview |
This recombinant human Peroxisomal Biogenesis Factor 19 (PEX19) protein includes amino acids 2-296aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P40855 |
| Recommended Name |
Peroxisomal biogenesis factor 19 |
| Gene Name |
PEX19 |
| Synonyms |
Peroxisomal biogenesis factor 19, D1S2223E, HK33, PMP1, PMPI, PXF, PXMP1. |
| Species |
Human |
| Predicted Molecular Mass |
36.0 kDa |
| Expression System |
E.coli |
| Expression Range |
2-296aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Tags & Cell Markers |
| Target Function |
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. |
| Subcellular Location |
Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side. |
| Protein Family |
Peroxin-19 family |
| Associated Diseases |
Peroxisome biogenesis disorder complementation group 14 (PBD-CG14); Peroxisome biogenesis disorder 12A (PBD12A) |
| Tissue Specificity |
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. |
