| Product Name |
Recombinant Human Oncostatin-M-Specific Receptor Subunit β/OSMRB/IL-31RB Protein |
| Product Overview |
This recombinant human Oncostatin-M-Specific Receptor Subunit β/OSMRB/IL-31RB protein includes amino acids 28-739aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q99650 |
| Recommended Name |
Oncostatin-M-specific receptor subunit beta |
| Gene Name |
OSMR |
| Synonyms |
Oncostatin-M-Specific Receptor Subunit Beta; Interleukin-31 Receptor Subunit Beta; IL-31 Receptor Su |
| Species |
Human |
| Predicted Molecular Mass |
82.0 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
28-739aa |
| Tag |
C-6His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. |
| Subcellular Location |
Membrane; Single-pass type I membrane protein. |
| Protein Family |
Type I cytokine receptor family, Type 2 subfamily |
| Associated Diseases |
Amyloidosis, primary localized cutaneous, 1 (PLCA1) |
| Tissue Specificity |
Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells. |
