| Product Name |
Recombinant Human MHC Class I Polypeptide Related Sequence A (MICA) Protein |
| Product Overview |
This recombinant human MHC Class I Polypeptide Related Sequence A (MICA) protein includes amino acids 24-307aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q29983 |
| Recommended Name |
MHC class I polypeptide-related sequence A |
| Gene Name |
MICA |
| Synonyms |
MHC class I polypeptide-related sequence A, PERB11.1, truncated. |
| Species |
Human |
| Predicted Molecular Mass |
63 kDa |
| Expression System |
E.coli |
| Expression Range |
24-307aa |
| Tag |
N-6His+GST |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Signal Transduction |
| Target Function |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cytoplasm. |
| Protein Family |
MHC class I family, MIC subfamily |
| Associated Diseases |
Psoriasis 1 (PSORS1); Psoriatic arthritis (PSORAS) |
| Tissue Specificity |
Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within t |
