| Product Name |
Recombinant Human Type I Inositol 1,4,5-Trisphosphate 5-Phosphatase/INPP5A Protein |
| Product Overview |
This recombinant human Type I Inositol 1,4,5-Trisphosphate 5-Phosphatase/INPP5A protein includes amino acids 1-410aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q14642 |
| Recommended Name |
Inositol polyphosphate-5-phosphatase A |
| Gene Name |
INPP5A |
| Synonyms |
Type I inositol 1;4;5-trisphosphate 5-phosphatase; INPP5A |
| Species |
Human |
| Predicted Molecular Mass |
48.5 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-410aa |
| Tag |
C-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Signal Transduction |
| Target Function |
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells. |
| Subcellular Location |
Cell membrane; Lipid-anchor. Cell projection, dendrite. |
| Protein Family |
Inositol 1,4,5-trisphosphate 5-phosphatase type I family |
| Tissue Specificity |
Predominantly expressed in heart, brain, and skeletal muscle. In brain; high level in Purkinje cells. |
