| Product Name |
Recombinant Human IL23R Protein |
| Product Overview |
This recombinant human IL23R protein includes amino acids 24-355aa of the target gene is expressed in Baculovirus-Insect Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q5VWK5 |
| Recommended Name |
Interleukin-23 receptor |
| Gene Name |
IL23R |
| Synonyms |
Interleukin-23 receptor, IL23R, IL 23R, IL-23 receptor, IL-23R, Il23r, IL23R_HUMAN, Interleukin 23 r |
| Species |
Human |
| Predicted Molecular Mass |
65.3 kDa |
| Expression System |
Insect Cell |
| Expression Range |
24-355aa |
| Tag |
N-6His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. |
| Protein Family |
Type I cytokine receptor family, Type 2 subfamily |
| Associated Diseases |
Inflammatory bowel disease 17 (IBD17) |
| Tissue Specificity |
Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. |
