| Product Name |
Recombinant Human Interleukin 12 Receptor Beta 1 (IL12Rb1) Protein |
| Product Overview |
This recombinant human Interleukin 12 Receptor Beta 1 (IL12Rb1) protein includes amino acids 37-234aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P42701 |
| Recommended Name |
Interleukin-12 receptor subunit beta-1 |
| Gene Name |
IL12RB1 |
| Synonyms |
Interleukin-12 receptor subunit beta-1, CD212, IL-12R-BETA1, IL12RB |
| Species |
Human |
| Predicted Molecular Mass |
23 kDa |
| Expression System |
E.coli |
| Expression Range |
37-234aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Subcellular Location |
Membrane; Single-pass type I membrane protein. |
| Protein Family |
Type I cytokine receptor family, Type 2 subfamily |
| Associated Diseases |
Immunodeficiency 30 (IMD30) |
