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Astor Scientific  |  SKU: ASTP7631

Human GZMB (Granzyme B) - Recombinant Protein

Molecule: GZMB
Species: Human
Expression System: E.coli
Tag: N-6His
Expression Range: 21-247aa
$429.99 $549.99
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SDS-PAGE analysis of Human GZMB (Granzyme B) - Recombinant Protein, showing >90% purity under 15% SDS-PAGE (Reduced)
Astor Scientific

Human GZMB (Granzyme B) - Recombinant Protein

$429.99 $549.99

Product Overview

Product Name Recombinant Human Granzyme B (GZMB) Protein
Product Overview This recombinant human Granzyme B (GZMB) protein includes amino acids 21-247aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization.
Target Uniprot Id P10144
Recommended Name Granzyme B
Gene Name GZMB
Synonyms Granzyme B, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species Human
Predicted Molecular Mass 31 kDa
Expression System E.coli
Expression Range 21-247aa
Tag N-6His
Purity >90%
Formulation Lyophilized
Buffer Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose
Storage Condition 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Reconstitution Instruction Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%.
Applications Positive Control; Immunogen; SDS-PAGE; WB
Research Area Immunology
Target Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location Secreted. Cytolytic granule.
Protein Family Peptidase S1 family, Granzyme subfamily

Size

  • 100ug
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