| Product Name |
Recombinant Human CD16b / FCGR3B Protein |
| Product Overview |
This recombinant human CD16b / FCGR3B protein includes amino acids 1-200aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
O75015 |
| Recommended Name |
Low affinity immunoglobulin gamma Fc region receptor III-B |
| Gene Name |
FCGR3B |
| Synonyms |
CD16;CD16b;Fc gamma RIIIb;FCG3;FCGR3;FCR-10;FCRIII;FCRIIIb |
| Species |
Human |
| Predicted Molecular Mass |
22.2 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-200aa |
| Tag |
C-His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage. |
| Tissue Specificity |
Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils. |
