| Product Name |
Recombinant Human BMPR1A Protein |
| Product Overview |
This recombinant human BMPR1A protein includes amino acids 24-152aa of the target gene is expressed in Baculovirus-Insect Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P36894 |
| Recommended Name |
Bone morphogenetic protein receptor type-1A |
| Gene Name |
BMPR1A |
| Synonyms |
Bone morphogenetic protein receptor type-1A, BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5 |
| Species |
Human |
| Predicted Molecular Mass |
41.4 kDa |
| Expression System |
Insect Cell |
| Expression Range |
24-152aa |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cardiovascular |
| Target Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cell surface. |
| Protein Family |
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily |
| Associated Diseases |
Juvenile polyposis syndrome (JPS); Polyposis syndrome, mixed hereditary 2 (HMPS2) |
| Tissue Specificity |
Highly expressed in skeletal muscle. |
