PD 123319 ditrifluoroacetate, Angiotensin II type II antagonist (TBI4959)

Description

Product Details

Formal Name: (6S)-1-[[4-(Dimethylamino)-3-methylphenylmethyl]-5-(2,2diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate

Molecular Formula: C₃₁H₃₂N₄O₃·2CF₃CO₂H

Formula Weight: 736.70

CAS Number: 136676-91-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or Water (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Angiotensin II type II antagonist

Functions

Potent (IC50 = 34 nM) and selective non-peptide angiotensin II type 2 (AT2) antagonist. Ameliorated symptoms of 2,4-dinitrobenzenesulfonic-induced colitis in rats via inhibition of NF-kB activation. PD123319 displayed protective effects in ischemia-reperfusion injury and oxidative damage in rat hearts.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.